Pain-care specialist agrees to testify against Purdue and other Opioid drugmakers

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Portenoy’s previously confidential cooperation agreement and declaration were made public Friday as a part of a discovery ruling by David Cohen, a special master in the federal court in Cleveland, Ohio, where hundreds of the opioid lawsuits have been consolidated. In an email, Cohen said it was possible the records should have been filed under seal out of public view.

Their disclosure offers a glimpse into the largely secretive evidence gathering phase of the litigation. Purdue executives have said the privately-held company is considering bankruptcy in the face of its potential liability. The company avoided having to stand as a defendant in a trial scheduled for May in Oklahoma by agreeing to pay the state $270 million.

Portenoy could not be reached for comment. His lawyer did not immediately respond to an email seeking comment.

Purdue spokesman Bob Josephson declined to comment on Portenoy’s declaration and new role in the litigation.

Other companies, including Endo and Mallinckrodt, did not immediately respond to requests for comment.

Portenoy, who has held leadership positions at Memorial Sloan-Kettering Cancer Center and Mount Sinai Beth Israel, was among the first physicians to espouse opioids as an option for the treatment of chronic pain, a condition that afflicts tens of millions of Americans, in medical journal articles published in the 1980s and 1990s. Later, he shared his views with physicians at conferences and in training videos sponsored by opioid makers, he said in the declaration.

Previously, physicians had been trained to reserve opioids for cancer and end-of-life pain. Opioids are chemically similar to heroin and the risk of addiction was viewed as too great for their widespread use.

In his declaration, Portenoy said he never altered his positions because of opioid makers’ payments for research, speeches, consulting and other work. But, he said, the companies paid only for work that supported their interests and cited it selectively “to promote opioids by referencing the positive statements that I made repeatedly without providing the background, analysis of the literature, and cautions that accompanied these positive statements.”

These “unbalanced communications” encouraged the prescribing of opioids to patients unsuited for them and by physicians who lacked the skills to manage addiction, abuse and overdose, Portenoy said. All of this, he concluded, “contributed to the rising incidence of drug addiction and overdoses.”

Opioids are involved in about 50,000 deaths a year in the United States. In an effort to staunch the toll, the U.S. Centers for Disease Control and Prevention in 2016 recommended against opioids as a first-line treatment for chronic pain.

In a tentative decision issued on Friday, special master Cohen ruled that Portenoy may serve as a witness for the plaintiffs — just not in the first trial scheduled to take place in federal court in Cleveland later this year. Cohen was responding to a complaint from the defendant companies that they had inadequate notice of Portenoy’s new role.

Josephson said Purdue believed the special master’s ruling was appropriate. He did not elaborate.

Source: CNBC

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